DUBs, new members in the hypoxia signaling clUb
click here Cellular protein homeostasis is tightly regulated by ubiquitination.Responsible for target protein ubiquitination is a class of enzymes, the so-called ubiquitin (Ub) E3-ligases.They are opposed to a second class of enzymes, called DeUBiquitinating enzymes (DUBs), which can remove polyubiquitin chains from their specific target proteins.T